| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAX |
| Gene ID: | 4149 |
| Uniprot ID: | MAX_HUMAN |
| Immunogen Region: | 1-160 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human MAX (NP_002373.3). |
| Immunogen Sequence: | MSDNDDIEVESDEEQPRFQS AADKRAHHNALERKRRDHIK DSFHSLRDSVPSLQGEKASR AQILDKATEYIQYMRRKNHT HQQDIDDLKRQNALLEQQVR ALEKARSSAQLQTNYPSSDN SLYTNAKGSTISAFDGGSDS SSESEPEEPQSRKKLRMEAS |
| Tissue Specificity | High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle. |
| Post Translational Modifications | Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes. |
| Function | Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CACGATG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. |
| Protein Name | Protein Max Class D Basic Helix-Loop-Helix Protein 4 Bhlhd4 Myc-Associated Factor X |
| Database Links | Reactome: R-HSA-1362277 Reactome: R-HSA-69202 Reactome: R-HSA-69656 Reactome: R-HSA-8953750 |
| Cellular Localisation | Nucleus Cell Projection Dendrite |
| Alternative Antibody Names | Anti-Protein Max antibody Anti-Class D Basic Helix-Loop-Helix Protein 4 antibody Anti-Bhlhd4 antibody Anti-Myc-Associated Factor X antibody Anti-MAX antibody Anti-BHLHD4 antibody |
Information sourced from Uniprot.org