| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MASP2 (445-686) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MASP2 |
| Gene ID: |
10747 |
| Uniprot ID: |
MASP2_HUMAN |
| Immunogen Region: |
445-686 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 445-686 of human MASP2 (NP_006601.2). |
| Immunogen Sequence: |
IYGGQKAKPGDFPWQVLILG GTTAAGALLYDNWVLTAAHA VYEQKHDASALDIRMGTLKR LSPHYTQAWSEAVFIHEGYT HDAGFDNDIALIKLNNKVVI NSNITPICLPRKEAESFMRT DDIGTASGWGLTQRGFLARN LMYVDIPIVDHQKCTAAYEK PPYPRGSVTANMLCAGLESG GKDSCRGDSGGALVFLDSET ERWFVGGIVSWGSMNCGEAG QYGVYTKVINYIPWIENII |
| Tissue Specificity | Plasma. |
| Post Translational Modifications | The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Activated by cleavage after Arg-444. The uncleaved zymogen is inactive towards synthetic substrates, but has sufficient activity to effect autocatalytic cleavage. |
| Function | Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. |
| Protein Name | Mannan-Binding Lectin Serine Protease 2Mbl-Associated Serine Protease 2Mannose-Binding Protein-Associated Serine Protease 2Masp-2 Cleaved Into - Mannan-Binding Lectin Serine Protease 2 A Chain - Mannan-Binding Lectin Serine Protease 2 B Chain |
| Database Links | Reactome: R-HSA-166662 O00187-1Reactome: R-HSA-166663 O00187-1Reactome: R-HSA-2855086 O00187-1Reactome: R-HSA-9705671 O00187-1 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Mannan-Binding Lectin Serine Protease 2 antibodyAnti-Mbl-Associated Serine Protease 2 antibodyAnti-Mannose-Binding Protein-Associated Serine Protease 2 antibodyAnti-Masp-2 Cleaved Into - Mannan-Binding Lectin Serine Protease 2 A Chain - Mannan-Binding Lectin Serine Protease 2 B Chain antibodyAnti-MASP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
