| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAP7 |
| Gene ID: | 9053 |
| Uniprot ID: | MAP7_HUMAN |
| Immunogen Region: | 490-749 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 490-749 of human MAP7 (NP_003971.1). |
| Immunogen Sequence: | AREQREKEERERREQEELER QKREELAQRVAEERTTRREE ESRRLEAEQAREKEEQLQRQ AEERALREREEAERAQRQKE EEARVREEAERVRQEREKHF QREEQERLERKKRLEEIMKR TRRTEATDKKTSDQRNGDIA KGALTGGTEVSALPCTTNAP GNGKPVGSPHVVTSHQSKVT VESTPDLEKQPNENGVSVQN ENFEEIINLPIGSKPSRLDV TNSESPEIPLNPILAFDDE |
| Tissue Specificity | Expressed in the skin and cells of epithelial origin. Predominantly expressed in the suprabasal layers of the normal epidermis and relatively abundant in squamous cell carcinomas but barely detectable in basal cell carcinomas. |
| Post Translational Modifications | The association with microtubules is regulated by phosphorylation during the cell cycle. During interphase only phosphorylated on serine. Phosphorylated on threonine in mitosis. |
| Function | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. |
| Protein Name | Ensconsin Epithelial Microtubule-Associated Protein Of 115 Kda E-Map-115 Microtubule-Associated Protein 7 Map-7 |
| Cellular Localisation | Cytoplasm Perinuclear Region Basolateral Cell Membrane Cytoskeleton Colocalized On Microtubules An Intracellular Redistribution Is Triggered During Induction Of Keratinocyte Terminal Differentiation From Microtubules With A Perinuclear Localization To Cortical Microtubules Organized In Spike-Like Bundles Facing Intercellular Contacts |
| Alternative Antibody Names | Anti-Ensconsin antibody Anti-Epithelial Microtubule-Associated Protein Of 115 Kda antibody Anti-E-Map-115 antibody Anti-Microtubule-Associated Protein 7 antibody Anti-Map-7 antibody Anti-MAP7 antibody |
Information sourced from Uniprot.org