| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:3000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAP3K13 |
| Gene ID: | 9175 |
| Uniprot ID: | M3K13_HUMAN |
| Immunogen Region: | 500-759 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 500-759 of human MAP3K13 (NP_001229246.1). |
| Immunogen Sequence: | CWRSSEPDKGQAGPWGCCQA DAYDPCLQCRPEQYGSLDIP SAEPVGRSPDLSKSPAHNPL LENAQSSEKTEENEFSGCRS ESSLGTSHLGTPPALPRKTR PLQKSGDDSSEEEEGEVDSE VEFPRRQRPHRCISSCQSYS TFSSENFSVSDGEEGNTSDH SNSPDELADKLEDRLAEKLD DLLSQTPEIPIDISSHSDGL SDKECAVRRVKTQMSLGKLC VEERGYENPMQFEESDCDS |
| Tissue Specificity | Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas. |
| Post Translational Modifications | Autophosphorylated on serine and threonine residues. |
| Function | Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase 13Leucine Zipper-Bearing KinaseMixed Lineage KinaseMlk |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase 13 antibodyAnti-Leucine Zipper-Bearing Kinase antibodyAnti-Mixed Lineage Kinase antibodyAnti-Mlk antibodyAnti-MAP3K13 antibodyAnti-LZK antibody |
Information sourced from Uniprot.org