| Tissue Specificity | Expressed in the aorta (at protein level). Isoform Long: Expressed in fibroblasts. |
| Post Translational Modifications | Contains hydroxylated asparagine residues. Isoform Short N-terminus is blocked. Two intrachain disulfide bonds from the TB3 domain are rearranged upon TGFB1 binding, and form interchain bonds with TGFB1 propeptide, anchoring it to the extracellular matrix. O-glycosylated on serine residues by POGLUT2 and POGLUT3. |
| Function | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta. |
| Protein Name | Latent-Transforming Growth Factor Beta-Binding Protein 1Ltbp-1Transforming Growth Factor Beta-1-Binding Protein 1Tgf-Beta1-Bp-1 |
| Database Links | Reactome: R-HSA-2129379Reactome: R-HSA-2173789Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Latent-Transforming Growth Factor Beta-Binding Protein 1 antibodyAnti-Ltbp-1 antibodyAnti-Transforming Growth Factor Beta-1-Binding Protein 1 antibodyAnti-Tgf-Beta1-Bp-1 antibodyAnti-LTBP1 antibody |
Information sourced from Uniprot.org
