| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
LNX1 |
| Gene ID: |
84708 |
| Uniprot ID: |
LNX1_HUMAN |
| Immunogen Region: |
480-620 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 480-620 of human LNX1 (NP_001119800.1). |
| Immunogen Sequence: |
NGSWSPGPGERSNTPKPLHP TITCHEKVVNIQKDPGESLG MTVAGGASHREWDLPIYVIS VEPGGVISRDGRIKTGDILL NVDGVELTEVSRSEAVALLK RTSSSIVLKALEVKEYEPQE DCSSPAALDSNHNMAPPSDW S |
| Tissue Specificity | Expressed in heart, placenta, kidney, pancreas and brain. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4. |
| Protein Name | E3 Ubiquitin-Protein Ligase LnxLigand Of Numb-Protein X 1Numb-Binding Protein 1Pdz Domain-Containing Ring Finger Protein 2Ring-Type E3 Ubiquitin Transferase Lnx |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Lnx antibodyAnti-Ligand Of Numb-Protein X 1 antibodyAnti-Numb-Binding Protein 1 antibodyAnti-Pdz Domain-Containing Ring Finger Protein 2 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Lnx antibodyAnti-LNX1 antibodyAnti-LNX antibodyAnti-PDZRN2 antibodyAnti-UNQ574 antibodyAnti-PRO1136 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
