| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LCP1 (368-627) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LCP1 |
| Gene ID: |
3936 |
| Uniprot ID: |
PLSL_HUMAN |
| Immunogen Region: |
368-627 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 368-627 of human L-Plastin/LCP1 (NP_002289.2). |
| Immunogen Sequence: |
ANLFNRYPALHKPENQDIDW GALEGETREERTFRNWMNSL GVNPRVNHLYSDLSDALVIF QLYEKIKVPVDWNRVNKPPY PKLGGNMKKLENCNYAVELG KNQAKFSLVGIGGQDLNEGN RTLTLALIWQLMRRYTLNIL EEIGGGQKVNDDIIVNWVNE TLREAKKSSSISSFKDPKIS TSLPVLDLIDAIQPGSINYD LLKTENLNDDEKLNNAKYAI SMARKIGARVYALPEDLVE |
| Tissue Specificity | Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells. |
| Post Translational Modifications | Phosphorylated on a serine residue in response to costimulation through TCR/CD3 and CD2 or CD28. Serine phosphorylation promotes association with the actin cytoskeleton and targeting to peripheral cell projections. |
| Function | Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. |
| Protein Name | Plastin-2L-PlastinLc64pLymphocyte Cytosolic Protein 1Lcp-1 |
| Database Links | Reactome: R-HSA-8950505 |
| Cellular Localisation | CytoplasmCytoskeletonCell JunctionCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SideRelocalizes To The Immunological Synapse Between Peripheral Blood T-Lymphocytes And Antibody-Presenting Cells In Response To Costimulation Through Tcr/Cd3 And Cd2 Or Cd28Associated With The Actin Cytoskeleton At Membrane RufflesRelocalizes To Actin-Rich Cell Projections Upon Serine Phosphorylation |
| Alternative Antibody Names | Anti-Plastin-2 antibodyAnti-L-Plastin antibodyAnti-Lc64p antibodyAnti-Lymphocyte Cytosolic Protein 1 antibodyAnti-Lcp-1 antibodyAnti-LCP1 antibodyAnti-PLS2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
