| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KRT1 (200-450) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KRT1 |
| Gene ID: |
3848 |
| Uniprot ID: |
K2C1_HUMAN |
| Immunogen Region: |
200-450 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 200-450 of human Cytokeratin 1 (Cytokeratin 1 (KRT1) ) (NP_006112.3). |
| Immunogen Sequence: |
FLEQQNQVLQTKWELLQQVD TSTRTHNLEPYFESFINNLR RRVDQLKSDQSRLDSELKNM QDMVEDYRNKYEDEINKRTN AENEFVTIKKDVDGAYMTKV DLQAKLDNLQQEIDFLTALY QAELSQMQTQISETNVILSM DNNRSLDLDSIIAEVKAQYE DIAQKSKAEAESLYQSKYEE LQITAGRHGDSVRNSKIEIS ELNRVIQRLRSEIDNVKKQI SNLQQSISDAEQRGENALK |
| Tissue Specificity | The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis. |
| Post Translational Modifications | Undergoes deimination of some arginine residues (citrullination). |
| Function | May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. |
| Protein Name | Keratin - Type Ii Cytoskeletal 167 Kda CytokeratinCytokeratin-1Ck-1Hair Alpha ProteinKeratin-1K1Type-Ii Keratin Kb1 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | Cell MembraneCytoplasm |
| Alternative Antibody Names | Anti-Keratin - Type Ii Cytoskeletal 1 antibodyAnti-67 Kda Cytokeratin antibodyAnti-Cytokeratin-1 antibodyAnti-Ck-1 antibodyAnti-Hair Alpha Protein antibodyAnti-Keratin-1 antibodyAnti-K1 antibodyAnti-Type-Ii Keratin Kb1 antibodyAnti-KRT1 antibodyAnti-KRTA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
