| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KHDRBS2 is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KHDRBS2 |
| Gene ID: |
202559 |
| Uniprot ID: |
KHDR2_HUMAN |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human KHDRBS2 (NP_689901.2). |
| Immunogen Sequence: |
TAPSRGRGGAIPPPPPPGRG VLTPRGSTVTRGALPVPPVA RGVPTPRARGAPTVPGYRAP PPPAHEAYEEYGYDDGYGGE YDDQTYETYDNSYATQTQSV PEYYDYGHGVSEDAYDSYAP EEWATTRSSLKAPPQRSARG GYREHPYGRY |
| Tissue Specificity | Highly expressed in brain, lung, kidney and small intestine. Weakly expressed in placenta, liver, spleen, thymus, ovary and colon. |
| Post Translational Modifications | Methylated. Tyrosine phosphorylated by FYN, PTK6 and SRC. Tyrosine phosphorylated by SRC during mitosis. |
| Function | RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis. |
| Protein Name | Kh Domain-Containing - Rna-Binding - Signal Transduction-Associated Protein 2Sam68-Like Mammalian Protein 1Slm-1Hslm-1 |
| Database Links | Reactome: R-HSA-8849468 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Kh Domain-Containing - Rna-Binding - Signal Transduction-Associated Protein 2 antibodyAnti-Sam68-Like Mammalian Protein 1 antibodyAnti-Slm-1 antibodyAnti-Hslm-1 antibodyAnti-KHDRBS2 antibodyAnti-SLM1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
