| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNMA1 (850-950) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNMA1 |
| Gene ID: |
3778 |
| Uniprot ID: |
KCMA1_HUMAN |
| Immunogen Region: |
850-950 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 850-950 of human KCNMA1 (NP_001258447.1). |
| Immunogen Sequence: |
SIGVLQANSQGFTPPGMDRS SPDNSPVHGMLRQPSITTGV NIPIITELVNDTNVQFLDQD DDDDPDTELYLTQPFACGTA FAVSVLDSLMSATYFNDNIL T |
| Tissue Specificity | Widely expressed. Except in myocytes, it is almost ubiquitously expressed. |
| Post Translational Modifications | Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity. Palmitoylation by ZDHHC22 and ZDHHC23 within the intracellular linker between the S0 and S1 transmembrane domains regulates localization to the plasma membrane. Depalmitoylated by LYPLA1 and LYPLAL1, leading to retard exit from the trans-Golgi network. |
| Function | Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). |
| Protein Name | Calcium-Activated Potassium Channel Subunit Alpha-1Bk ChannelBkca AlphaCalcium-Activated Potassium Channel - Subfamily M Subunit Alpha-1K(VcaalphaKca1.1Maxi K ChannelMaxikSlo-AlphaSlo1Slowpoke HomologSlo HomologHslo |
| Database Links | Reactome: R-HSA-1296052Reactome: R-HSA-418457Reactome: R-HSA-9662360Reactome: R-HSA-9667769 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Calcium-Activated Potassium Channel Subunit Alpha-1 antibodyAnti-Bk Channel antibodyAnti-Bkca Alpha antibodyAnti-Calcium-Activated Potassium Channel - Subfamily M Subunit Alpha-1 antibodyAnti-K(Vcaalpha antibodyAnti-Kca1.1 antibodyAnti-Maxi K Channel antibodyAnti-Maxik antibodyAnti-Slo-Alpha antibodyAnti-Slo1 antibodyAnti-Slowpoke Homolog antibodyAnti-Slo Homolog antibodyAnti-Hslo antibodyAnti-KCNMA1 antibodyAnti-KCNMA antibodyAnti-SLO antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
