| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNJ11 (171-390) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNJ11 |
| Gene ID: |
3767 |
| Uniprot ID: |
KCJ11_HUMAN |
| Immunogen Region: |
171-390 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 171-390 of human KCNJ11 (NP_000516.3). |
| Immunogen Sequence: |
TAQAHRRAETLIFSKHAVIA LRHGRLCFMLRVGDLRKSMI ISATIHMQVVRKTTSPEGEV VPLHQVDIPMENGVGGNSIF LVAPLIIYHVIDANSPLYDL APSDLHHHQDLEIIVILEGV VETTGITTQARTSYLADEIL WGQRFVPIVAEEDGRYSVDY SKFGNTVKVPTPLCTARQLD EDHSLLEALTLASARGPLRK RSVPMAKAKPKFSISPDSLS |
| Post Translational Modifications | Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity. |
| Function | This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. |
| Protein Name | Atp-Sensitive Inward Rectifier Potassium Channel 11IkatpInward Rectifier K(+ Channel Kir6.2Potassium Channel - Inwardly Rectifying Subfamily J Member 11 |
| Database Links | Reactome: R-HSA-1296025Reactome: R-HSA-382556Reactome: R-HSA-422356Reactome: R-HSA-5578775Reactome: R-HSA-5678420Reactome: R-HSA-5683177 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Sensitive Inward Rectifier Potassium Channel 11 antibodyAnti-Ikatp antibodyAnti-Inward Rectifier K(+ Channel Kir6.2 antibodyAnti-Potassium Channel - Inwardly Rectifying Subfamily J Member 11 antibodyAnti-KCNJ11 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
