| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KATNA1 (1-167) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KATNA1 |
| Gene ID: |
11104 |
| Uniprot ID: |
KTNA1_HUMAN |
| Immunogen Region: |
1-167 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-167 of human KATNA1 (NP_001191005.1). |
| Immunogen Sequence: |
MSLLMISENVKLAREYALLG NYDSAMVYYQGVLDQMNKYL YSVKDTYLQQKWQQVWQEIN VEAKHVKDIMKTLESFKLDS TPLKAAQHDLPASEGEVWSM PVPVERRPSPGPRKRQSSQY SDPKSHGNRPSTTVRVHRSS AQNVHNDRGKAVRCREKKEQ NKGREEK |
| Post Translational Modifications | Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation. Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation. |
| Function | Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. |
| Protein Name | Katanin P60 Atpase-Containing Subunit A1Katanin P60 Subunit A1P60 Katanin |
| Cellular Localisation | CytoplasmMidbodyCytoskeletonMicrotubule Organizing CenterCentrosomeSpindle PoleSpindlePredominantly CytoplasmicLocalized Diffusely In The Cytoplasm During The InterphaseDuring Metaphase Is Localized Throughout The Cell And More Widely Dispersed Than The MicrotubulesIn Anaphase And Telophase Is Localized At The Midbody RegionAlso Localized To The Interphase Centrosome And The Mitotic Spindle PolesEnhanced Recruitment To The Mitotic Spindle Poles Requires Microtubules And Interaction With Katnb1Localizes Within The CytoplasmPartially Overlapping With MicrotubulesIn Interphase And To The Mitotic Spindle And Spindle Poles During Mitosis |
| Alternative Antibody Names | Anti-Katanin P60 Atpase-Containing Subunit A1 antibodyAnti-Katanin P60 Subunit A1 antibodyAnti-P60 Katanin antibodyAnti-KATNA1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
