| Tissue Specificity | Widely expressed. Isoform 1 is predominantly expressed in heart and kidney. Isoform 2 probably is widely expressed at basic levels. |
| Function | Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis. At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge. Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing. Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors.this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia.this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading.this function is partially mediated by BAIAP2. In the nucleus, is involved in beta-catenin-dependent activation of transcription. During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis. Potential tumor suppressor for renal cell carcinoma (Probable). |
| Protein Name | Kn Motif And Ankyrin Repeat Domain-Containing Protein 1Ankyrin Repeat Domain-Containing Protein 15Kidney Ankyrin Repeat-Containing Protein |
| Database Links | Reactome: R-HSA-9018519Reactome: R-HSA-9673768 |
| Cellular Localisation | CytoplasmCell CortexCell ProjectionRuffle MembranePeripheral Membrane ProteinNucleusShuttles Between The Cytoplasm And NucleusColocalizes With Cmsc Components At Focal Adhesion RimsColocalizes With Kif21a In Membrane RufflesColocalizes With Rhoa At The Contractile RingColocalizes With Rhoa And Daam1 Around CentrosomesIsoform 1: CytoplasmIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Kn Motif And Ankyrin Repeat Domain-Containing Protein 1 antibodyAnti-Ankyrin Repeat Domain-Containing Protein 15 antibodyAnti-Kidney Ankyrin Repeat-Containing Protein antibodyAnti-KANK1 antibodyAnti-ANKRD15 antibodyAnti-KANK antibodyAnti-KIAA0172 antibody |
Information sourced from Uniprot.org
