Anti-JAM-C antibody [CRAM-18 F26] (STJ16100484)

SKU:
STJ16100484-1

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Host: Mouse
Applications: IHC-F/FC/ELISA/IP
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-JAM-C is suitable for use in Immunohistochemistry, Flow Cytometry, ELISA and Immunoprecipitation research applications.
Clonality: Monoclonal
Clone ID: CRAM-18 F26
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: PBS with 0.1% BSA and 0.02% sodium azide
Concentration: 100 ug/mL
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: JAM3
Gene ID: 83700
Uniprot ID: JAM3_HUMAN
Tissue Specificity Detected on round and elongated spermatids (at protein level). Highest expression in placenta, brain and kidney. Significant expression is detected on platelets. Expressed in intestinal mucosa cells. Expressed in the vascular endothelium. Found in serum (at protein level). Also detected in the synovial fluid of patients with rheumatoid arthritis, psoriatic arthritis or ostearthritis (at protein level).
Post Translational Modifications Proteolytically cleaved from endothelial cells surface into a soluble form by ADAM10 and ADAM17.the release of soluble JAM3 is increased by pro-inflammatory factors. S-palmitoylated by ZDHHC7. S-palmitoylation promotes expression at tight junctions.
Function Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium. Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation. Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). Plays a role in angiogenesis. Plays a role in the regulation of cell migration (Probable). During myogenesis, it is involved in myocyte fusion. Soluble form of JAM-C: Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis.
Protein Name Junctional Adhesion Molecule C
Jam-C
Jam-2
Junctional Adhesion Molecule 3
Jam-3 Cleaved Into - Soluble Form Of Jam-C
Sjam-C
Database Links Reactome: R-HSA-202733
Reactome: R-HSA-216083
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Desmosome
Tight Junction
Detected In The Acrosome Region In Developing Spermatids
In Epithelial Cells
It Is Expressed At Desmosomes But Not At Tight Junctions
Localizes At The Cell Surface Of Endothelial Cells
Treatment Of Endothelial Cells With Vascular Endothelial Growth Factor Stimulates Recruitment Of Jam3 To Cell-Cell Contacts
Soluble Form Of Jam-C: Secreted
Alternative Antibody Names Anti-Junctional Adhesion Molecule C antibody
Anti-Jam-C antibody
Anti-Jam-2 antibody
Anti-Junctional Adhesion Molecule 3 antibody
Anti-Jam-3 Cleaved Into - Soluble Form Of Jam-C antibody
Anti-Sjam-C antibody
Anti-JAM3 antibody
Anti-UNQ859 antibody
Anti-PRO1868 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance