| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ITGA5 |
| Gene ID: | 3678 |
| Uniprot ID: | ITA5_HUMAN |
| Immunogen Region: | 42-995 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-995 of human Integrin alpha 5 (ITGA5/CD49e) (NP_002196.4). |
| Immunogen Sequence: | FNLDAEAPAVLSGPPGSFFG FSVEFYRPGTDGVSVLVGAP KANTSQPGVLQGGAVYLCPW GASPTQCTPIEFDSKGSRLL ESSLSSSEGEEPVEYKSLQW FGATVRAHGSSILACAPLYS WRTEKEPLSDPVGTCYLSTD NFTRILEYAPCRSDFSWAAG QGYCQGGFSAEFTKTGRVVL GGPGSYFWQGQILSATQEQI AESYYPEYLINLVQGQLQTR QASSIYDDSYLGYSVAVGE |
| Tissue Specificity | Expressed in placenta (at protein level). |
| Post Translational Modifications | Proteolytic cleavage by PCSK5 mediates activation of the precursor. |
| Function | Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling. (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. |
| Protein Name | Integrin Alpha-5 Cd49 Antigen-Like Family Member E Fibronectin Receptor Subunit Alpha Integrin Alpha-F Vla-5 Cd Antigen Cd49e Cleaved Into - Integrin Alpha-5 Heavy Chain - Integrin Alpha-5 Light Chain |
| Database Links | Reactome: R-HSA-1566948 Reactome: R-HSA-1566977 Reactome: R-HSA-202733 Reactome: R-HSA-216083 Reactome: R-HSA-445144 Reactome: R-HSA-8941332 Reactome: R-HSA-9634597 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Cell Junction Focal Adhesion |
| Alternative Antibody Names | Anti-Integrin Alpha-5 antibody Anti-Cd49 Antigen-Like Family Member E antibody Anti-Fibronectin Receptor Subunit Alpha antibody Anti-Integrin Alpha-F antibody Anti-Vla-5 antibody Anti-Cd Antigen Cd49e Cleaved Into - Integrin Alpha-5 Heavy Chain - Integrin Alpha-5 Light Chain antibody Anti-ITGA5 antibody Anti-FNRA antibody |
Information sourced from Uniprot.org