| Tissue Specificity | In general, low constitutive expression, if any, in healthy tissues.high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart. |
| Post Translational Modifications | Proteolytically converted to the mature form by CASP1. |
| Function | Immune regulatory cytokine that acts as a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. Signaling can occur via two mechanisms, intracellularly through nuclear translocation with SMAD3 and extracellularly after secretion and binding to its receptor composed of IL18R1 and IL18RAP. Suppresses, or reduces, pro-inflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. |
| Protein Name | Interleukin-37Il-37Fil1 ZetaIl-1xInterleukin-1 Family Member 7Il-1f7Interleukin-1 Homolog 4Il-1hIl-1h4Interleukin-1 ZetaIl-1 ZetaInterleukin-1-Related ProteinIl-1rp1 |
| Database Links | Reactome: R-HSA-9008059Reactome: R-HSA-9012546 |
| Cellular Localisation | CytoplasmCytosolNucleusSecretedStimulation With Il1b Leads To Colocalization With Smad3 Mostly In Perinuclear RegionsOnly The Casp1-Cleaved Mature Form Translocates Into The Nucleus Upon Lps StimulationThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Antibody Names | Anti-Interleukin-37 antibodyAnti-Il-37 antibodyAnti-Fil1 Zeta antibodyAnti-Il-1x antibodyAnti-Interleukin-1 Family Member 7 antibodyAnti-Il-1f7 antibodyAnti-Interleukin-1 Homolog 4 antibodyAnti-Il-1h antibodyAnti-Il-1h4 antibodyAnti-Interleukin-1 Zeta antibodyAnti-Il-1 Zeta antibodyAnti-Interleukin-1-Related Protein antibodyAnti-Il-1rp1 antibodyAnti-IL37 antibodyAnti-FIL1Z antibodyAnti-IL1F7 antibodyAnti-IL1H4 antibodyAnti-IL1RP1 antibody |
Information sourced from Uniprot.org
