| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IL36RN (1-155) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL36RN |
| Gene ID: |
26525 |
| Uniprot ID: |
I36RA_HUMAN |
| Immunogen Region: |
1-155 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-155 of human IL36RN (NP_036407.1). |
| Immunogen Sequence: |
MVLSGALCFRMKDSALKVLY LHNNQLLAGGLHAGKVIKGE EISVVPNRWLDASLSPVILG VQGGSQCLSCGVGQEPTLTL EPVNIMELYLGAKESKSFTF YRRDMGLTSSFESAAYPGWF LCTVPEADQPVRLTQLPENG GWNAPITDFYFQQCD |
| Tissue Specificity | Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. |
| Function | Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response.similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. |
| Protein Name | Interleukin-36 Receptor Antagonist ProteinIl-36raFil1 DeltaIl-1-Related Protein 3Il-1rp3Interleukin-1 Hy1Il-1hy1Interleukin-1 DeltaIl-1 DeltaInterleukin-1 Family Member 5Il-1f5Interleukin-1 Receptor Antagonist Homolog 1Il-1ra Homolog 1Interleukin-1-Like Protein 1Il-1l1 |
| Database Links | Reactome: R-HSA-9014826 |
| Cellular Localisation | CytoplasmSecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Antibody Names | Anti-Interleukin-36 Receptor Antagonist Protein antibodyAnti-Il-36ra antibodyAnti-Fil1 Delta antibodyAnti-Il-1-Related Protein 3 antibodyAnti-Il-1rp3 antibodyAnti-Interleukin-1 Hy1 antibodyAnti-Il-1hy1 antibodyAnti-Interleukin-1 Delta antibodyAnti-Il-1 Delta antibodyAnti-Interleukin-1 Family Member 5 antibodyAnti-Il-1f5 antibodyAnti-Interleukin-1 Receptor Antagonist Homolog 1 antibodyAnti-Il-1ra Homolog 1 antibodyAnti-Interleukin-1-Like Protein 1 antibodyAnti-Il-1l1 antibodyAnti-IL36RN antibodyAnti-FIL1D antibodyAnti-IL1F5 antibodyAnti-IL1HY1 antibodyAnti-IL1L1 antibodyAnti-IL1RP3 antibodyAnti-UNQ1896 antibodyAnti-PRO4342 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and ITCH knockout (KO) 293T cells, using [KO Validated] ITCH Rabbit polyclonal antibody (STJ118061) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/96951/379801/STJ118061_1__34949.1713147667.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and ITCH knockout (KO) 293T cells, using [KO Validated] ITCH Rabbit polyclonal antibody (STJ118061) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.")
