| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HTR3B (22-238) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HTR3B |
| Gene ID: |
9177 |
| Uniprot ID: |
5HT3B_HUMAN |
| Immunogen Region: |
22-238 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 22-238 of human HTR3B (NP_006019.1). |
| Immunogen Sequence: |
TDTHHPQDSALYHLSKQLLQ KYHKEVRPVYNWTKATTVYL DLFVHAILDVDAENQILKTS VWYQEVWNDEFLSWNSSMFD EIREISLPLSAIWAPDIIIN EFVDIERYPDLPYVYVNSSG TIENYKPIQVVSACSLETYA FPFDVQNCSLTFKSILHTVE DVDLAFLRSPEDIQHDKKAF LNDSEWELLSVSSTYSILQS SAGGFAQIQFNVVMRRH |
| Tissue Specificity | Expressed in the brain cortex, in the caudate nucleus, the hippocampus, the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus, prostate, ovary and placenta. |
| Post Translational Modifications | N-glycosylation required for membrane localization. |
| Function | Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons. |
| Protein Name | 5-Hydroxytryptamine Receptor 3b5-Ht3-B5-Ht3bSerotonin Receptor 3b |
| Database Links | Reactome: R-HSA-112314 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell MembranePresumably Retained Within The Endoplasmic Reticulum Unless Complexed With Htr3a |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 3b antibodyAnti-5-Ht3-B antibodyAnti-5-Ht3b antibodyAnti-Serotonin Receptor 3b antibodyAnti-HTR3B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
