• Western blot analysis of various lysates using HSD17B6 Rabbit polyclonal antibody (STJ116684) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

Anti-HSD17B6 antibody (178-317) (STJ116684)

SKU:
STJ116684

Shipping:
Free Shipping
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-HSD17B6 (178-317) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: HSD17B6
Gene ID: 8630
Uniprot ID: H17B6_HUMAN
Immunogen Region: 178-317
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 178-317 of human HSD17B6 (NP_003716.2).
Immunogen Sequence: VSKYGVEAFSDILRREIQHF GVKISIVEPGYFRTGMTNMT QSLERMKQSWKEAPKHIKET YGQQYFDALYNIMKEGLLNC STNLNLVTDCMEHALTSVHP RTRYSAGWDAKFFFIPLSYL PTSLADYILTRSWPKPAQAV
Tissue Specificity Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain.
Function NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.
Protein Name 17-Beta-Hydroxysteroid Dehydrogenase Type 6
17-Beta-Hsd 6
17-Beta-Hsd6
3-Alpha->Beta-Hydroxysteroid Epimerase
3-Alpha->Beta-Hse
Oxidative 3-Alpha Hydroxysteroid Dehydrogenase
Short Chain Dehydrogenase/Reductase Family 9c Member 6
Database Links Reactome: R-HSA-2453902
Cellular Localisation Microsome Membrane
Peripheral Membrane Protein
Lumenal Side
Early Endosome Membrane
Alternative Antibody Names Anti-17-Beta-Hydroxysteroid Dehydrogenase Type 6 antibody
Anti-17-Beta-Hsd 6 antibody
Anti-17-Beta-Hsd6 antibody
Anti-3-Alpha->Beta-Hydroxysteroid Epimerase antibody
Anti-3-Alpha->Beta-Hse antibody
Anti-Oxidative 3-Alpha Hydroxysteroid Dehydrogenase antibody
Anti-Short Chain Dehydrogenase/Reductase Family 9c Member 6 antibody
Anti-HSD17B6 antibody
Anti-RODH antibody
Anti-SDR9C6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance