| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HR (200-480) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HR |
| Gene ID: |
55806 |
| Uniprot ID: |
HAIR_HUMAN |
| Immunogen Region: |
200-480 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 200-480 of human HR (NP_005135.2). |
| Immunogen Sequence: |
SLGSKGFYYKDPSIPRLAKE PLAAAEPGLFGLNSGGHLQR AGEAERPSLHQRDGEMGAGR QQNPCPLFLGQPDTVPWTSW PACPPGLVHTLGNVWAGPGD GNLGYQLGPPATPRCPSPEP PVTQRGCCSSYPPTKGGGLG PCGKCQEGLEGGASGASEPS EEVNKASGPRACPPSHHTKL KKTWLTRHSEQFECPRGCPE VEERPVARLRALKRAGSPEV QGAMGSPAPKRPPDPFPGT |
| Tissue Specificity | Strongest expression of isoforms 1 and 2 is seen in the small intestine, weaker expression in brain and colon, and trace expression is found in liver, pancreas, spleen, thymus, stomach, salivary gland, appendix and trachea. Isoform 1 is always the most abundant. Isoform 1 is exclusively expressed at low levels in kidney and testis. Isoform 2 is exclusively expressed at high levels in the skin. |
| Function | Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. |
| Protein Name | Lysine-Specific Demethylase HairlessHistone H3-Dimethyl-L-Lysine(9 Demethylase Hairless |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase Hairless antibodyAnti-Histone H3-Dimethyl-L-Lysine(9 Demethylase Hairless antibodyAnti-HR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
