| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HMGN3 (1-77) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HMGN3 |
| Gene ID: |
9324 |
| Uniprot ID: |
HMGN3_HUMAN |
| Immunogen Region: |
1-77 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-77 of human HMGN3 (NP_620058.1). |
| Immunogen Sequence: |
MPKRKSPENTEGKDGSKVTK QEPTRRSARLSAKPAPPKPE PKPRKTSAKKEPGAKISRGA KGKKEEKQEAGKEGTEN |
| Tissue Specificity | Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries. |
| Function | Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function. |
| Protein Name | High Mobility Group Nucleosome-Binding Domain-Containing Protein 3Thyroid Receptor-Interacting Protein 7Tr-Interacting Protein 7Trip-7 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-High Mobility Group Nucleosome-Binding Domain-Containing Protein 3 antibodyAnti-Thyroid Receptor-Interacting Protein 7 antibodyAnti-Tr-Interacting Protein 7 antibodyAnti-Trip-7 antibodyAnti-HMGN3 antibodyAnti-TRIP7 antibodyAnti-PNAS-24 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
