| Tissue Specificity | Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries. |
| Function | Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function. |
| Protein Name | High Mobility Group Nucleosome-Binding Domain-Containing Protein 3Thyroid Receptor-Interacting Protein 7Tr-Interacting Protein 7Trip-7 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-High Mobility Group Nucleosome-Binding Domain-Containing Protein 3 antibodyAnti-Thyroid Receptor-Interacting Protein 7 antibodyAnti-Tr-Interacting Protein 7 antibodyAnti-Trip-7 antibodyAnti-HMGN3 antibodyAnti-TRIP7 antibodyAnti-PNAS-24 antibody |
Information sourced from Uniprot.org
