| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LAX1 (77-398) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LAX1 |
| Gene ID: |
54900 |
| Uniprot ID: |
LAX1_HUMAN |
| Immunogen Region: |
77-398 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 77-398 of human LAX1 (NP_060243.2). |
| Immunogen Sequence: |
MPLLTLPQTRQRAKNIYDIL PWRQEDLGRHESRSMRIFST ESLLSRNSESPEHVPSQAGN AFQEHTAHIHATEYAVGIYD NAMVPQMCGNLTPSAHCINV RASRDCASISSEDSHDYVNV PTAEEIAETLASTKSPSRNL FVLPSTQKLEFTEERDEGCG DAGDCTSLYSPGAEDSDSLS NGEGSSQISNDYVNMTGLDL SAIQERQLWVAFQCCRDYEN VPAADPSGSQQQAEKDVPS |
| Tissue Specificity | Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines. |
| Post Translational Modifications | Phosphorylated on tyrosines by Syk, Lck or ZAP70 upon TCR or BCR activation.which leads to the recruitment of GRB2, PIK3R1 and GRAP2. |
| Function | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells. |
| Protein Name | Lymphocyte Transmembrane Adapter 1Linker For Activation Of X CellsMembrane-Associated Adapter Protein Lax |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane Protein |
| Alternative Antibody Names | Anti-Lymphocyte Transmembrane Adapter 1 antibodyAnti-Linker For Activation Of X Cells antibodyAnti-Membrane-Associated Adapter Protein Lax antibodyAnti-LAX1 antibodyAnti-LAX antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
