| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GTF2H1 |
| Gene ID: | 2965 |
| Uniprot ID: | TF2H1_HUMAN |
| Immunogen Region: | 1-425 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-425 of human GTF2H1 (NP_001135779.1). |
| Immunogen Sequence: | MATSSEEVLLIVKKVRQKKQ DGALYLMAERIAWAPEGKDR FTISHMYADIKCQKISPEGK AKIQLQLVLHAGDTTNFHFS NESTAVKERDAVKDLLQQLL PKFKRKANKELEEKNRMLQE DPVLFQLYKDLVVSQVISAE EFWANRLNVNATDSSSTSNH KQDVGISAAFLADVRPQTDG CNGLRYNLTSDIIESIFRTY PAVKMKYAENVPHNMTEKEF WTRFFQSHYFHRDRLNTGS |
| Function | Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. |
| Protein Name | General Transcription Factor Iih Subunit 1 Basic Transcription Factor 2 62 Kda Subunit Btf2 P62 General Transcription Factor Iih Polypeptide 1 Tfiih Basal Transcription Factor Complex P62 Subunit |
| Database Links | Reactome: R-HSA-112382 Reactome: R-HSA-113418 Reactome: R-HSA-167152 Reactome: R-HSA-167158 Reactome: R-HSA-167160 Reactome: R-HSA-167161 Reactome: R-HSA-167162 Reactome: R-HSA-167172 Reactome: R-HSA-167200 Reactome: R-HSA-167246 Reactome: R-HSA-427413 Reactome: R-HSA-5696395 Reactome: R-HSA-5696400 Reactome: R-HSA-674695 Reactome: R-HSA-6781823 Reactome: R-HSA-6781827 Reactome: R-HSA-6782135 Reactome: R-HSA-6782210 Reactome: R-HSA-6796648 Reactome: R-HSA-72086 Reactome: R-HSA-73762 Reactome: R-HSA-73772 Reactome: R-HSA-73776 Reactome: R-HSA-73779 Reactome: R-HSA-73863 Reactome: R-HSA-75953 Reactome: R-HSA-75955 Reactome: R-HSA-76042 Reactome: R-HSA-77075 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-General Transcription Factor Iih Subunit 1 antibody Anti-Basic Transcription Factor 2 62 Kda Subunit antibody Anti-Btf2 P62 antibody Anti-General Transcription Factor Iih Polypeptide 1 antibody Anti-Tfiih Basal Transcription Factor Complex P62 Subunit antibody Anti-GTF2H1 antibody Anti-BTF2 antibody |
Information sourced from Uniprot.org