| Tissue Specificity | Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system. |
| Function | Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer. |
| Protein Name | Ovarian Cancer G-Protein Coupled Receptor 1Ogr-1G-Protein Coupled Receptor 68Gpr12aSphingosylphosphorylcholine Receptor |
| Database Links | Reactome: R-HSA-373076Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Ovarian Cancer G-Protein Coupled Receptor 1 antibodyAnti-Ogr-1 antibodyAnti-G-Protein Coupled Receptor 68 antibodyAnti-Gpr12a antibodyAnti-Sphingosylphosphorylcholine Receptor antibodyAnti-GPR68 antibodyAnti-OGR1 antibody |
Information sourced from Uniprot.org
