| Tissue Specificity | Expressed in pancreas (at protein level). Specifically expressed by M (microfold) cells which are atypical epithelial cells of the intestine (at protein level). |
| Post Translational Modifications | N-glycosylated. Glycosylated Asn-65 may be required for interaction with bacterial adhesin fimH. |
| Function | Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response. |
| Protein Name | Pancreatic Secretory Granule Membrane Major Glycoprotein Gp2Pancreatic Zymogen Granule Membrane Protein Gp-2Zap75 |
| Database Links | Reactome: R-HSA-163125 |
| Cellular Localisation | Zymogen Granule MembraneLipid-AnchorGpi-AnchorSecretedCell MembraneApical Cell MembraneMembrane RaftEndosomeAfter CleavageIn The Pancreatic Juice |
| Alternative Antibody Names | Anti-Pancreatic Secretory Granule Membrane Major Glycoprotein Gp2 antibodyAnti-Pancreatic Zymogen Granule Membrane Protein Gp-2 antibodyAnti-Zap75 antibodyAnti-GP2 antibody |
Information sourced from Uniprot.org
