| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-GNB4 (1-340) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GNB4 |
| Gene ID: | 59345 |
| Uniprot ID: | GBB4_HUMAN |
| Immunogen Region: | 1-340 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-340 of human GNB4 (NP_067642.1). |
| Immunogen Sequence: | MSELEQLRQEAEQLRNQIQD ARKACNDATLVQITSNMDSV GRIQMRTRRTLRGHLAKIYA MHWGYDSRLLVSASQDGKLI IWDSYTTNKMHAIPLRSSWV MTCAYAPSGNYVACGGLDNI CSIYNLKTREGNVRVSRELP GHTGYLSCCRFLDDSQIVTS SGDTTCALWDIETAQQTTTF TGHSGDVMSLSLSPDMRTFV SGACDASSKLWDIRDGMCRQ SFTGHVSDINAVSFFPNGY |
| Tissue Specificity | Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves. |
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
| Protein Name | Guanine Nucleotide-Binding Protein Subunit Beta-4Transducin Beta Chain 4 |
| Database Links | Reactome: R-HSA-1296041Reactome: R-HSA-163359Reactome: R-HSA-202040Reactome: R-HSA-381676Reactome: R-HSA-392170Reactome: R-HSA-392451Reactome: R-HSA-392851Reactome: R-HSA-400042Reactome: R-HSA-4086398Reactome: R-HSA-416476Reactome: R-HSA-416482Reactome: R-HSA-418217Reactome: R-HSA-418555Reactome: R-HSA-418592Reactome: R-HSA-418594Reactome: R-HSA-418597Reactome: R-HSA-420092Reactome: R-HSA-428930Reactome: R-HSA-432040Reactome: R-HSA-456926Reactome: R-HSA-500657Reactome: R-HSA-6814122Reactome: R-HSA-8964315Reactome: R-HSA-8964616Reactome: R-HSA-9009391Reactome: R-HSA-9634597Reactome: R-HSA-9660821Reactome: R-HSA-997272 |
| Alternative Antibody Names | Anti-Guanine Nucleotide-Binding Protein Subunit Beta-4 antibodyAnti-Transducin Beta Chain 4 antibodyAnti-GNB4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunofluorescence analysis of HeLa cells using [KO Validated] DNAJB1 Rabbit polyclonal antibody (STJ27455) at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/101151/388526/STJ27455_1__36817.1713158040.jpg?c=1 "Immunofluorescence analysis of HeLa cells using [KO Validated] DNAJB1 Rabbit polyclonal antibody (STJ27455) at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.")