| Tissue Specificity | Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen. Trace amounts where seen in kidney, adrenal gland and liver. Found to be expressed in all the insulinomas examined. |
| Function | Guanine nucleotide-binding protein (G protein) involved as transducer in olfactory signal transduction controlled by G protein-coupled receptors (GPCRs). Contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. GNAL/G(olf) alpha specifically mediates olfactory signal transduction within the olfactory neuroepithelium and the basal ganglia following GPCRs activation. Acts by promoting the specific activation of adenylyl cyclase ADCY3, resulting in increased levels of the signaling molecule cAMP. |
| Protein Name | Guanine Nucleotide-Binding Protein G(Olf Subunit AlphaAdenylate Cyclase-Stimulating G Alpha Protein - Olfactory Type |
| Database Links | Reactome: R-HSA-170660Reactome: R-HSA-170670Reactome: R-HSA-381753 |
| Cellular Localisation | Cell MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Guanine Nucleotide-Binding Protein G(Olf Subunit Alpha antibodyAnti-Adenylate Cyclase-Stimulating G Alpha Protein - Olfactory Type antibodyAnti-GNAL antibody |
Information sourced from Uniprot.org
