| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GLRB (23-265) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GLRB |
| Gene ID: |
2743 |
| Uniprot ID: |
GLRB_HUMAN |
| Immunogen Region: |
23-265 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 23-265 of human GLRB (NP_000815.1). |
| Immunogen Sequence: |
KEKSSKKGKGKKKQYLCPSQ QSAEDLARVPANSTSNILNR LLVSYDPRIRPNFKGIPVDV VVNIFINSFGSIQETTMDYR VNIFLRQKWNDPRLKLPSDF RGSDALTVDPTMYKCLWKPD LFFANEKSANFHDVTQENIL LFIFRDGDVLVSMRLSITLS CPLDLTLFPMDTQRCKMQLE SFGYTTDDLRFIWQSGDPVQ LEKIALPQFDIKKEDIEYGN CTKYYKGTGYYTCVEVIFT |
| Function | Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. |
| Protein Name | Glycine Receptor Subunit BetaGlycine Receptor 58 Kda Subunit |
| Database Links | Reactome: R-HSA-112314 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinSynapseCell ProjectionDendriteCell MembraneCytoplasmRetained In The Cytoplasm Upon Heterologous Expression By ItselfCoexpression With Gphn Promotes Expression At The Cell MembraneCoexpression With Glra1Glra2 Or Glra3 Promotes Expression At The Cell Membrane |
| Alternative Antibody Names | Anti-Glycine Receptor Subunit Beta antibodyAnti-Glycine Receptor 58 Kda Subunit antibodyAnti-GLRB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of various lysates using [KO Validated] SHMT2 Rabbit polyclonal antibody (STJ25526) at 1:400 dilution incubated overnight at 4 °C. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic KitExposure time: 30 s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/100514/387105/STJ25526_1__79760.1713156306.jpg?c=1 "Western blot analysis of various lysates using [KO Validated] SHMT2 Rabbit polyclonal antibody (STJ25526) at 1:400 dilution incubated overnight at 4 °C. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic KitExposure time: 30 s.")