| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GLRA1 (29-247) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GLRA1 |
| Gene ID: |
2741 |
| Uniprot ID: |
GLRA1_HUMAN |
| Immunogen Region: |
29-247 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 29-247 of human GLRA1 (NP_000162.2). |
| Immunogen Sequence: |
ARSAPKPMSPSDFLDKLMGR TSGYDARIRPNFKGPPVNVS CNIFINSFGSIAETTMDYRV NIFLRQQWNDPRLAYNEYPD DSLDLDPSMLDSIWKPDLFF ANEKGAHFHEITTDNKLLRI SRNGNVLYSIRITLTLACPM DLKNFPMDVQTCIMQLESFG YTMNDLIFEWQEQGAVQVAD GLTLPQFILKEEKDLRYCTK HYNTGKFTCIEARFHLERQ |
| Function | Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Channel characteristics depend on the subunit composition.heteropentameric channels are activated by lower glycine levels and display faster desensitization. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol. Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol. |
| Protein Name | Glycine Receptor Subunit Alpha-1Glycine Receptor 48 Kda SubunitGlycine Receptor Strychnine-Binding Subunit |
| Database Links | Reactome: R-HSA-112314 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinSynapsePerikaryonCell ProjectionDendriteCell Membrane |
| Alternative Antibody Names | Anti-Glycine Receptor Subunit Alpha-1 antibodyAnti-Glycine Receptor 48 Kda Subunit antibodyAnti-Glycine Receptor Strychnine-Binding Subunit antibodyAnti-GLRA1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
