| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Germ cell nuclear acidic protein (444-494 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GCNA |
| Gene ID: | 93953 |
| Uniprot ID: | GCNA_HUMAN |
| Immunogen Region: | 444-494 aa |
| Specificity: | This antibody detects endogenous levels of ACRC at Human |
| Immunogen: | Synthesized peptide derived from the human ACRC at the amino acid range 444-494 |
| Function | May play a role in DNA-protein cross-links (DPCs) clearance through a SUMO-dependent recruitment to sites of DPCs, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage. Can resolve the topoisomerase II (TOP2A) DPCs. |
| Protein Name | Germ Cell Nuclear Acidic ProteinAcidic Repeat-Containing ProteinGerm Cell Nuclear Acidic PeptidaseGerm Cell Nuclear Antigen |
| Cellular Localisation | NucleusPml BodyChromosomeCo-Localizes With Sumo2 At Pml Bodies In All Interphase CellsLocalizes On Condensed Chromosomes In Spermatocytes In G2 And M During Meiotic Prophase |
| Alternative Antibody Names | Anti-Germ Cell Nuclear Acidic Protein antibodyAnti-Acidic Repeat-Containing Protein antibodyAnti-Germ Cell Nuclear Acidic Peptidase antibodyAnti-Germ Cell Nuclear Antigen antibodyAnti-GCNA antibodyAnti-ACRC antibody |
Information sourced from Uniprot.org