Anti-GAK nanobody [SAA1190] (STJN000038)

Anti-GAK nanobody [SAA1190] (STJN000038)

SKU:
STJN000038
£378.50 - £1,632.50
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Covered by St John's Laboratory Guarantee

Host: Alpaca
Applications: ELISA/SPR
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Cyclin-G-Associated Kinase is suitable for use in ELISA and SPR research applications.
Clonality : Monoclonal
Clone ID : SAA1190
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: GAK
Gene ID: 2580
Uniprot ID: GAK_HUMAN
Function Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly.
Protein Name Cyclin-G-Associated Kinase
Dnaj Homolog Subfamily C Member 26
Database Links Reactome: R-HSA-432722
Reactome: R-HSA-8856828
Cellular Localisation Cytoplasm
Perinuclear Region
Golgi Apparatus
Trans-Golgi Network
Cell Junction
Focal Adhesion
Cytoplasmic Vesicle
Clathrin-Coated Vesicle
Localizes To The Perinuclear Area And To The Trans-Golgi Network
Also Seen On The Plasma Membrane
Probably At Focal Adhesions
Recruitment To Clathrin-Coated Vesicles Depends On Temporal Variations In Phosphoinositide Composition Of Clathrin-Coated Vesicles
Alternative Nanobody Names Anti-Cyclin-G-Associated Kinase nanobody
Anti-Dnaj Homolog Subfamily C Member 26 nanobody
Anti-GAK nanobody
Anti-DNAJC26 nanobody

Information sourced from Uniprot.org

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