• Western blot analysis of extracts of various cell lines, using GABRA2 antibody (STJ116118) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 3s.

Anti-GABRA2 antibody (300-400) (STJ116118)

SKU:
STJ116118

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-GABRA2 (300-400) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GABRA2
Gene ID: 2555
Uniprot ID: GBRA2_HUMAN
Immunogen Region: 300-400
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 300-400 of human GABRA2 (NP_000798.2).
Immunogen Sequence: ARNSLPKVAYATAMDWFIAV CYAFVFSALIEFATVNYFTK RGWAWDGKSVVNDKKKEKAS VMIQNNAYAVAVANYAPNLS KDPVLSTISKSATTPEPNKK P
Post Translational Modifications Glycosylated.
Function Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity.
Protein Name Gamma-Aminobutyric Acid Receptor Subunit Alpha-2
Gaba(A Receptor Subunit Alpha-2
Database Links Reactome: R-HSA-977443
Cellular Localisation Postsynaptic Cell Membrane
Multi-Pass Membrane Protein
Cell Membrane
Cytoplasmic Vesicle Membrane
Cell Projection
Dendrite
Alternative Antibody Names Anti-Gamma-Aminobutyric Acid Receptor Subunit Alpha-2 antibody
Anti-Gaba(A Receptor Subunit Alpha-2 antibody
Anti-GABRA2 antibody

Information sourced from Uniprot.org

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