| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GABRA2 |
| Gene ID: |
2555 |
| Uniprot ID: |
GBRA2_HUMAN |
| Immunogen Region: |
300-400 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human GABRA2 (NP_000798.2). |
| Immunogen Sequence: |
ARNSLPKVAYATAMDWFIAV CYAFVFSALIEFATVNYFTK RGWAWDGKSVVNDKKKEKAS VMIQNNAYAVAVANYAPNLS KDPVLSTISKSATTPEPNKK P |
| Post Translational Modifications | Glycosylated. |
| Function | Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces. When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. The alpha-2 subunit exhibits synaptogenic activity together with beta-2 and very little to no activity together with beta-3, the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation. |
| Protein Name | Gamma-Aminobutyric Acid Receptor Subunit Alpha-2Gaba(A Receptor Subunit Alpha-2Gabaar Subunit Alpha-2 |
| Database Links | Reactome: R-HSA-977443 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmic Vesicle MembraneCell ProjectionDendrite |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Receptor Subunit Alpha-2 antibodyAnti-Gaba(A Receptor Subunit Alpha-2 antibodyAnti-Gabaar Subunit Alpha-2 antibodyAnti-GABRA2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
