| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FLRT2 (300-400) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FLRT2 |
| Gene ID: |
23768 |
| Uniprot ID: |
FLRT2_HUMAN |
| Immunogen Region: |
300-400 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human FLRT2 (NP_037363.1). |
| Immunogen Sequence: |
SNLKQLTARNNPWFCDCSIK WVTEWLKYIPSSLNVRGFMC QGPEQVRGMAVRELNMNLLS CPTTTPGLPLFTPAPSTASP TTQPPTLSIPNPSRSYTPPT P |
| Tissue Specificity | Expressed in pancreas, skeletal muscle, brain, and heart. |
| Post Translational Modifications | N-glycosylated. Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease. |
| Function | Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis. |
| Protein Name | Leucine-Rich Repeat Transmembrane Protein Flrt2Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 2 |
| Database Links | Reactome: R-HSA-5654687 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinEndoplasmic Reticulum MembraneCell JunctionFocal AdhesionSecretedExtracellular SpaceExtracellular MatrixMicrosome MembraneSynapseSynaptosomeProteolytic Cleavage Gives Rise To A Shedded Ectodomain |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat Transmembrane Protein Flrt2 antibodyAnti-Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 2 antibodyAnti-FLRT2 antibodyAnti-KIAA0405 antibodyAnti-UNQ232 antibodyAnti-PRO265 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
