| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000 IHC-P:1:100-1:500 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FERMT2 |
| Gene ID: | 10979 |
| Uniprot ID: | FERM2_HUMAN |
| Immunogen Region: | 380-550 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 380-550 of human FERMT2 (NP_006823.1). |
| Immunogen Sequence: | KVFKPKKLTLKGYKQYWCTF KDTSISCYKSKEESSGTPAH QMNLRGCEVTPDVNISGQKF NIKLLIPVAEGMNEIWLRCD NEKQYAHWMAACRLASKGKT MADSSYNLEVQNILSFLKMQ HLNPDPQLIPEQITTDITPE CLVSPRYLKKYKNKQITARI LEAHQNVAQMS |
| Tissue Specificity | Ubiquitous. Found in numerous tumor tissues. |
| Function | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading.this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. |
| Protein Name | Fermitin Family Homolog 2 Kindlin-2 Mitogen-Inducible Gene 2 Protein Mig-2 Pleckstrin Homology Domain-Containing Family C Member 1 Ph Domain-Containing Family C Member 1 |
| Database Links | Reactome: R-HSA-446353 Reactome: R-HSA-9013149 Reactome: R-HSA-9013423 |
| Cellular Localisation | Cytoplasm Cell Cortex Cytoskeleton Stress Fiber Cell Junction Focal Adhesion Membrane Peripheral Membrane Protein Cytoplasmic Side Cell Projection Lamellipodium Membrane Nucleus Myofibril Sarcomere I Band Cell Surface Colocalizes With Actin Stress Fibers At Cell-Ecm Focal Adhesion Sites Colocalizes With Itgb3 At Lamellipodia At The Leading Edge Of Spreading Cells Binds To Membranes That Contain Phosphatidylinositides |
| Alternative Antibody Names | Anti-Fermitin Family Homolog 2 antibody Anti-Kindlin-2 antibody Anti-Mitogen-Inducible Gene 2 Protein antibody Anti-Mig-2 antibody Anti-Pleckstrin Homology Domain-Containing Family C Member 1 antibody Anti-Ph Domain-Containing Family C Member 1 antibody Anti-FERMT2 antibody Anti-KIND2 antibody Anti-MIG2 antibody Anti-PLEKHC1 antibody |
Information sourced from Uniprot.org