| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FBN2 (2733-2912) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FBN2 |
| Gene ID: |
2201 |
| Uniprot ID: |
FBN2_HUMAN |
| Immunogen Region: |
2733-2912 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 2733-2912 of human FBN2 (NP_001990.2). |
| Immunogen Sequence: |
CVSGMGFNKGQYLSLDTEVD EENALSPEACYECKINGYSK KDSRQKRSIHEPDPTAVEQI SLESVDMDSPVNMKFNLSHL GSKEHILELRPAIQPLNNHI RYVISQGNDDSVFRIHQRNG LSYLHTAKKKLMPGTYTLEI TSIPLYKKKELKKLEESNED DYLLGELGEALRMRLQIQLY |
| Tissue Specificity | Almost exclusively expressed in placenta. Expressed at much lower level in other tissues. Expressed in fetal eye (18 weeks)in the retinal pigment epithelium (RPE), the choroid, Bruch's membrane and in the sclera. Not expressed in the neural retina. Placensin: Present at high level in cytotrophoblasts as compared with syncytiotrophoblasts at 8-9 weeks of pregnancy (at protein level). Levels in the serum increase during pregnancy (at protein level). |
| Post Translational Modifications | Placensin: N-glycosylated. O-glycosylated on serine residues by POGLUT2 and POGLUT3. |
| Function | Fibrillin-2: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Placensin: Hormone secreted by trophoblasts that promotes trophoblast invasiveness. Has glucogenic activity: is able to increase plasma glucose levels. |
| Protein Name | Fibrillin-2 Cleaved Into - Placensin |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-1566948Reactome: R-HSA-2129379 |
| Cellular Localisation | SecretedFibrillin-2 And Placensin Chains Are Still Linked Together During The Secretion From CellsBut Are Subsequently Separated By FurinFibrillin-2: SecretedExtracellular SpaceExtracellular MatrixPlacensin: SecretedSecreted By Placental Cells |
| Alternative Antibody Names | Anti-Fibrillin-2 Cleaved Into - Placensin antibodyAnti-FBN2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
