| Post Translational Modifications | Phosphorylation enhances DNA-binding. Highly susceptible to proteolysis. |
| Function | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex. Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development. Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes. Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent. May also regulate transcription through direct binding to DNA or transcription factors. |
| Protein Name | Nucleosome-Remodeling Factor Subunit BptfBromodomain And Phd Finger-Containing Transcription FactorFetal Alz-50 Clone 1 ProteinFetal Alzheimer Antigen |
| Cellular Localisation | CytoplasmNucleusLocalizes To Sites Of Dna DamageIn Brains Of Alzheimer Disease PatientsPresent In A Subset Of Amyloid-Containing Plaques |
| Alternative Antibody Names | Anti-Nucleosome-Remodeling Factor Subunit Bptf antibodyAnti-Bromodomain And Phd Finger-Containing Transcription Factor antibodyAnti-Fetal Alz-50 Clone 1 Protein antibodyAnti-Fetal Alzheimer Antigen antibodyAnti-BPTF antibodyAnti-FAC1 antibodyAnti-FALZ antibody |
Information sourced from Uniprot.org
