| Post Translational Modifications | Undergoes proteolytic cleavage.produces a 45 kDa N-terminal homeodomain-containing fragment (ESXR1-N) and a 20 kDa C-terminal fragment (ESXR1-C). |
| Function | May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. |
| Protein Name | Homeobox Protein Esx1Extraembryonic - Spermatogenesis - Homeobox 1 Cleaved Into - Homeobox Protein Esx1-N - Homeobox Protein Esx1-C |
| Cellular Localisation | CytoplasmNucleusEsxr1-N Localizes Specifically To The Nucleus While Esxr1-C Localizes Specifically To The Cytoplasm |
| Alternative Antibody Names | Anti-Homeobox Protein Esx1 antibodyAnti-Extraembryonic - Spermatogenesis - Homeobox 1 Cleaved Into - Homeobox Protein Esx1-N - Homeobox Protein Esx1-C antibodyAnti-ESX1 antibodyAnti-ESX1L antibodyAnti-ESX1R antibody |
Information sourced from Uniprot.org
