Anti-DYM antibody (1-250) (STJ110521)

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STJ110521

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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DYM
Gene ID: 54808
Uniprot ID: DYM_HUMAN
Immunogen Region: 1-250
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human DYM (NP_060123.3).
Immunogen Sequence: MGSNSSRIGDLPKNEYLKKL SGTESISENDPFWNQLLSFS FPAPTSSSELKLLEEATISV CRSLVENNPRTGNLGALIKV FLSRTKELKLSAECQNHIFI WQTHNALFIICCLLKVFICQ MSEEELQLHFTYEEKSPGNY SSDSEDLLEELLCCLMQLIT DIPLLDITYEISVEAISTMV VFLSCQLFHKEVLRQSISHK YLMRGPCLPYTSKLVKTLLY NFIRQEKPPPPGAHVFPQQ
Tissue Specificity Expressed in most embryo-fetal and adult tissues. Abundant in primary chondrocytes, osteoblasts, cerebellum, kidney, lung, stomach, heart, pancreas and fetal brain. Very low or no expression in the spleen, thymus, esophagus, bladder and thyroid gland.
Post Translational Modifications Myristoylated in vitro.myristoylation is not essential for protein targeting to Golgi compartment.
Function Necessary for correct organization of Golgi apparatus. Involved in bone development.
Protein Name Dymeclin
Dyggve-Melchior-Clausen Syndrome Protein
Cellular Localisation Cytoplasm
Golgi Apparatus
Membrane
Lipid-Anchor
Sequence Analysis Programs Clearly Predict 1 Transmembrane Region
However
Pubmed:18996921 Shows That It Is Not A Stably Anchored Transmembrane Protein But It Weakly Associates With The Golgi Apparatus And Shuttles Between The Golgi And The Cytosol
Alternative Antibody Names Anti-Dymeclin antibody
Anti-Dyggve-Melchior-Clausen Syndrome Protein antibody
Anti-DYM antibody

Information sourced from Uniprot.org

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