| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DSG4 |
| Gene ID: |
147409 |
| Uniprot ID: |
DSG4_HUMAN |
| Immunogen Region: |
480-630 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 480-630 of human DSG4 (NP_817123.1). |
| Immunogen Sequence: |
TGTICIEVPDINDYCPNIFP ERRTICIDSPSVLISVNEHS YGSPFTFCVVDEPPGIADMW DVRSTNATSAILTAKQVLSP GFYEIPILVKDSYNRACELA QMVQLYACDCDDNHMCLDSG AAGIYTEDITGDTYGPVTED QAGVSNVGLGP |
| Tissue Specificity | In scalp follicles, present in the inner root sheath (IRS) and all layers of the matrix and precortex (at protein level). Expressed in the brain, muscle, kidney, pancreas, spleen, thymus and weakly expressed in the lung, liver, heart and placenta. Highly expressed in skin, testis and prostate.less in salivary gland. |
| Function | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. Plays a role in moderating lymphocyte migration to inflamed skin and maintaining homeostasis of the epidermal inflammatory response. |
| Protein Name | Desmoglein-4Cadherin Family Member 13 |
| Database Links | Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionDesmosomeColocalizes With Jup At Desmosomes |
| Alternative Antibody Names | Anti-Desmoglein-4 antibodyAnti-Cadherin Family Member 13 antibodyAnti-DSG4 antibodyAnti-CDHF13 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
