| Tissue Specificity | Ubiquitously expressed with higher expression in kidney and ovary and lower expression in brain, colon and thymus. Also expressed in renal cell carcinomas, brain tumors, and in a part of melanomas and adenocarcinomas from organs other than the breast. Expressed in squamous cell carcinomas (SCC), glioma, and some adenocarcinoma cell lines, but not in breast cancer cell lines or any normal tissues (at protein level). |
| Post Translational Modifications | N-glycosylated. Glycosylation is important for enzymatic activity. |
| Function | Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate. |
| Protein Name | Dermatan-Sulfate EpimeraseDs EpimeraseChondroitin-Glucuronate 5-EpimeraseSquamous Cell Carcinoma Antigen Recognized By T-Cells 2Sart-2 |
| Database Links | Reactome: R-HSA-2022923 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneCytoplasmic Vesicle MembraneMicrosome Membrane |
| Alternative Antibody Names | Anti-Dermatan-Sulfate Epimerase antibodyAnti-Ds Epimerase antibodyAnti-Chondroitin-Glucuronate 5-Epimerase antibodyAnti-Squamous Cell Carcinoma Antigen Recognized By T-Cells 2 antibodyAnti-Sart-2 antibodyAnti-DSE antibodyAnti-SART2 antibody |
Information sourced from Uniprot.org
