| Host: | Rabbit |
| Applications: | WB/ICC |
| Reactivity: | Chicken/Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Draxin (C-Term) is suitable for use in Western Blot and Immunocytochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: | Antigen Affinity Purified |
| Dilution Range: | WB 1:1000ICC 1:100 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DRAXIN |
| Gene ID: | 374946 |
| Uniprot ID: | DRAXI_HUMAN |
| Immunogen Region: | C-Term |
| Specificity: | The antibody detects a significant 50 kDa* protein corresponding to the molecular mass of draxin on SDS-PAGE immunoblots of rat PC12 cells, rat P1 brain, and chick E9 brain. The antibody also shows low expression of draxin in adult mouse brain. |
| Immunogen: | Draxin synthetic peptide (coupled to KLH) corresponding to amino acid residues in the C-terminal region of human draxin. This peptide sequence is highly conserved in rat, mouse, and chick draxin. |
| Function | Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. |
| Protein Name | DraxinDorsal Inhibitory Axon Guidance ProteinDorsal Repulsive Axon Guidance ProteinNeucrin |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Draxin antibodyAnti-Dorsal Inhibitory Axon Guidance Protein antibodyAnti-Dorsal Repulsive Axon Guidance Protein antibodyAnti-Neucrin antibodyAnti-DRAXIN antibodyAnti-C1orf187 antibodyAnti-PSEC0258 antibodyAnti-UNQ3119 antibodyAnti-PRO10268 antibody |
Information sourced from Uniprot.org