| Function | May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. |
| Protein Name | Zinc Finger Protein Neuro-D4Brg1-Associated Factor 45bBaf45bD4 - Zinc And Double Phd Fingers Family 1 |
| Database Links | Reactome: R-HSA-9824585Reactome: R-HSA-9845323 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Zinc Finger Protein Neuro-D4 antibodyAnti-Brg1-Associated Factor 45b antibodyAnti-Baf45b antibodyAnti-D4 - Zinc And Double Phd Fingers Family 1 antibodyAnti-DPF1 antibodyAnti-BAF45B antibodyAnti-NEUD4 antibody |
Information sourced from Uniprot.org
