| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DPF1 (295-414) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DPF1 |
| Gene ID: |
8193 |
| Uniprot ID: |
DPF1_HUMAN |
| Immunogen Region: |
295-414 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 295-414 of human DPF1 (NP_001128627.1). |
| Immunogen Sequence: |
VIPNGYCDFCLGGSKKTGCP EDLISCADCGRSGHPSCLQF TVNMTAAVRTYRWQCIECKS CSLCGTSENDDQLLFCDDCD RGYHMYCLSPPMAEPPEGSW SCHLCLRHLKEKASAYITLT |
| Function | May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. |
| Protein Name | Zinc Finger Protein Neuro-D4Brg1-Associated Factor 45bBaf45bD4 - Zinc And Double Phd Fingers Family 1 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Zinc Finger Protein Neuro-D4 antibodyAnti-Brg1-Associated Factor 45b antibodyAnti-Baf45b antibodyAnti-D4 - Zinc And Double Phd Fingers Family 1 antibodyAnti-DPF1 antibodyAnti-BAF45B antibodyAnti-NEUD4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and IDH1 knockout (KO) HeLa cells, using [KO Validated] IDH1 Rabbit polyclonal antibody (STJ119996) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3min.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/98781/382830/STJ119996_1__99034.1713151333.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and IDH1 knockout (KO) HeLa cells, using [KO Validated] IDH1 Rabbit polyclonal antibody (STJ119996) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3min.")
