Anti-DKC1 antibody (245-514) (STJ23384)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DKC1 (245-514) antibody for use in IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DKC1 |
| Gene ID | 1736 |
| Uniprot ID | DKC1_HUMAN |
| Immunogen Region | 245-514 |
| Immunogen Sequence | ELRRVRSGVMSEKDHMVTMH DVLDAQWLYDNHKDESYLRR VVYPLEKLLTSHKRLVMKDS AVNAICYGAKIMLPGVLRYE DGIEVNQEIVVITTKGEAIC MAIALMTTAVISTCDHGIVA KIKRVIMERDTYPRKWGLGP KASQKKLMIKQGLLDKHGKP TDSTPATWKQEYVDYSESAK KEVVAEVVKAPQVVAEAAKT AKRKRESESESDETPPAAPQ LIKKEKKKSKKDKKAKAGL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 245-514 of human DKC1 (NP_001354.1). |
Additional Info
| Tissue Specificity | Ubiquitously expressed. |
| Function | Isoform 1: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. Isoform 3: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression. |
| Protein Name | H/Aca Ribonucleoprotein Complex Subunit Dkc1Cbf5 HomologDyskerinNopp140-Associated Protein Of 57 KdaNucleolar Protein Nap57Nucleolar Protein Family A Member 4Snornp Protein Dkc1 |
| Database Links | Reactome: R-HSA-171319Reactome: R-HSA-6790901 |
| Cellular Localisation | Isoform 1: NucleusNucleolusNucleusCajal BodyIsoform 3: Cytoplasm |
| Alternative Antibody Names | Anti-H/Aca Ribonucleoprotein Complex Subunit Dkc1 antibodyAnti-Cbf5 Homolog antibodyAnti-Dyskerin antibodyAnti-Nopp140-Associated Protein Of 57 Kda antibodyAnti-Nucleolar Protein Nap57 antibodyAnti-Nucleolar Protein Family A Member 4 antibodyAnti-Snornp Protein Dkc1 antibodyAnti-DKC1 antibodyAnti-NOLA4 antibody |
Information sourced from Uniprot.org