| Post Translational Modifications | Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC2. Phosphorylated at Ser-286, Ser-287 and Ser-291 in response to mitogenic stimulation by MTOR: DEPTOR is either directly phosphorylated by MTOR or indirectly via proteins kinases that are activated by MTOR, such as CK1/CSNK1A1. Phosphorylation at Ser-286, Ser-287 and Ser-291 promotes ubiquitination by the SCF(BTRC) complex, followed by degradation. Phosphorylation at Ser-235 by MAPK3/ERK1 promotes deubiquitination by USP7, enhancing its stability. Phosphorylation at Tyr-289 by SYK impairs its interaction with MTOR, promoting mTORC1 and mTORC2 signaling. Ubiquitinated.leading to proteasomal degradation. Ubiquitination by the SCF(BTRC) and SCF(FBXW11) complexes following phosphorylation at Ser-286, Ser-287 and Ser-291 by MTOR, leads to its degradation by the proteasome. Deubiquitinated by OTUB1 in response to amino acid via a non-canonical mechanism, leading to DEPTOR stability. Deubiquitinated by USP7 following phosphorylation at Ser-235, promoting its stability. |
| Function | Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes. DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy. In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity. |
| Protein Name | Dep Domain-Containing Mtor-Interacting ProteinHdeptorDep Domain-Containing Protein 6 |
| Cellular Localisation | Lysosome MembraneLocalizes To The Lysosomal Membrane When Associated With The Mtorc1 And Mtorc2 Complexes |
| Alternative Antibody Names | Anti-Dep Domain-Containing Mtor-Interacting Protein antibodyAnti-Hdeptor antibodyAnti-Dep Domain-Containing Protein 6 antibodyAnti-DEPTOR antibodyAnti-DEPDC6 antibody |
Information sourced from Uniprot.org
