| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DCUN1D1 (15-70) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DCUN1D1 |
| Gene ID: |
54165 |
| Uniprot ID: |
DCNL1_HUMAN |
| Immunogen Region: |
15-70 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 15-70 of human DCUN1D1 (NP_065691.2). |
| Immunogen Sequence: |
FMIFTQSSEKTAVSCLSQND WKLDVATDNFFQNPELYIRE SVKGSLDRKKLEQLYN |
| Tissue Specificity | Expressed in pancreas, kidney, placenta, brain and heart. Weakly or not expressed in liver, skeletal muscle and lung. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas. |
| Post Translational Modifications | Mono- and poly-ubiquitinated by ARIH2 and ARIH1. Monoubiquitination by ARIH2 is mediated by an interaction between autoubiquitinated ARIH2 and the UBA-like domain. The monoubiquitinated form preferentially interacts with non-neddylated cullins and modulates cullin RING ligase (CRL) complex composition and activity. |
| Function | Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression. |
| Protein Name | Dcn1-Like Protein 1Dcnl1Dcun1 Domain-Containing Protein 1Defective In Cullin Neddylation Protein 1-Like Protein 1Squamous Cell Carcinoma-Related Oncogene |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | NucleusCytoplasmThe Ubiquitinated Form Is Localized In The Cytoplasm |
| Alternative Antibody Names | Anti-Dcn1-Like Protein 1 antibodyAnti-Dcnl1 antibodyAnti-Dcun1 Domain-Containing Protein 1 antibodyAnti-Defective In Cullin Neddylation Protein 1-Like Protein 1 antibodyAnti-Squamous Cell Carcinoma-Related Oncogene antibodyAnti-DCUN1D1 antibodyAnti-DCN1 antibodyAnti-DCUN1L1 antibodyAnti-RP42 antibodyAnti-SCCRO antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
