| Post Translational Modifications | Glycosylated. |
| Function | Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions. |
| Protein Name | Dendritic Cell-Specific Transmembrane ProteinDc-StampHdc-StampDendrocyte-Expressed Seven Transmembrane ProteinIl-Four-Induced ProteinFindTransmembrane 7 Superfamily Member 4 |
| Database Links | Reactome: R-HSA-8874211 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneEndoplasmic Reticulum-Golgi Intermediate Compartment MembraneEndosomeLocalizes To The Cell Surface In Osteoclasts And Undifferentiated MonocytesIntracellular Internalized Dcstamp Is Detected In A Fraction Of Rankl-Induced Osteoclast PrecursorColocalizes With Os9 In The Endoplasmic Reticulum (Er) Of Immature Dendritic Cell (Dc)Translocates From The Endoplasmic Reticulum To The Intermediate/Golgi Compartment Upon Maturation Of Dc In A Os9-Dependent MannerColocalizes With Lamp1 In Endosomes |
| Alternative Antibody Names | Anti-Dendritic Cell-Specific Transmembrane Protein antibodyAnti-Dc-Stamp antibodyAnti-Hdc-Stamp antibodyAnti-Dendrocyte-Expressed Seven Transmembrane Protein antibodyAnti-Il-Four-Induced Protein antibodyAnti-Find antibodyAnti-Transmembrane 7 Superfamily Member 4 antibodyAnti-DCSTAMP antibodyAnti-TM7SF4 antibody |
Information sourced from Uniprot.org
