| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DCC (1000-1100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DCC |
| Gene ID: |
1630 |
| Uniprot ID: |
DCC_HUMAN |
| Immunogen Region: |
1000-1100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1000-1100 of human DCC (NP_005206.2). |
| Immunogen Sequence: |
ISGDRLTHQIMDLNLDTMYY FRIQARNSKGVGPLSDPILF RTLKVEHPDKMANDQGRHGD GGYWPVDTNLIDRSTLNEPP IGQMHPPHGSVTPQKNSNLL V |
| Tissue Specificity | Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells. |
| Post Translational Modifications | Ubiquitinated.mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. |
| Function | Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. |
| Protein Name | Netrin Receptor DccColorectal Cancer SuppressorImmunoglobulin Superfamily Dcc Subclass Member 1Tumor Suppressor Protein Dcc |
| Database Links | Reactome: R-HSA-373752Reactome: R-HSA-376172Reactome: R-HSA-418885Reactome: R-HSA-418886Reactome: R-HSA-418889Reactome: R-HSA-418890Reactome: R-HSA-428542 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Netrin Receptor Dcc antibodyAnti-Colorectal Cancer Suppressor antibodyAnti-Immunoglobulin Superfamily Dcc Subclass Member 1 antibodyAnti-Tumor Suppressor Protein Dcc antibodyAnti-DCC antibodyAnti-IGDCC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
